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Updated: Aug 20, 2026

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
Published on: July 18, 2025
Metabolic disorders in patients with liver cirrhosis
Masahiko Kato1, Hisataka Moriwaki
1The School of Life Studies, Sugiyama Jyogakuen University, 17-3, Motomachi, Hoshigaoka Chikusa-ku, Nagoya 464-8622, Japan.
Abstract:
Protein-energy malnutrition is frequently observed in patients with liver cirrhosis, and disorders of protein metabolism and energy metabolism closely correlate with this malnutrition. It has been demonstrated that in the process of protein metabolism, the synthesis and degradation rate of albumin decrease, and its half-life in the blood extends. Regarding energy metabolism, there is no consensus on energy expenditure, but there is a consensus that respiratory quotients are lower in patients with liver cirrhosis than in healthy people. These metabolic disorders also closely correlate with the prognosis of patients. Therefore, for clinicians it is important to improve metabolic disorders in patients with liver cirrhosis. Currently, it is assumed that supplementation with branched-chain amino acids is useful for improving disorders of protein metabolism, and that LES is useful for improving disorders of energy metabolism.
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