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The multiple sclerosis functional composite: different practice effects in the three test components.

Alessandra Solari1, Davide Radice, Letizia Manneschi

  • 1Laboratory of Epidemiology, National Neurological Institute C. Besta, Milan, Italy. solari@istituto-besta.it

Journal of the Neurological Sciences
|December 21, 2004
PubMed
Summary
This summary is machine-generated.

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The Multiple Sclerosis Functional Composite (MSFC) shows excellent reliability for clinical trials. Practice effects vary among its tests, suggesting optimized administration for accurate results.

Area of Science:

  • Neurology
  • Clinical Trials
  • Rehabilitation Medicine

Background:

  • The Multiple Sclerosis Functional Composite (MSFC) is a key outcome measure in multiple sclerosis (MS) clinical trials.
  • It integrates three tests: Timed 25-foot Walk (T25FW), Paced Auditory Serial Addition Test (PASAT), and 9-Hole Peg Test (9HP).

Purpose of the Study:

  • To evaluate the interrater and intrarater reliability of the MSFC.
  • To assess practice and fatigue effects associated with MSFC testing.

Main Methods:

  • 32 MS outpatients were assessed by two neurologists after training.
  • Each patient underwent four assessments by one examiner and two by another.
  • Testing occurred within a single day with rest periods, random order, and blinded examiners.

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Main Results:

  • Excellent interrater reliability was observed (ICC 0.93-0.99).
  • Excellent intrarater reliability was also found (ICC 0.93-0.98).
  • No practice effect was noted for T25FW after the first test; PASAT and 9HP showed improvement over initial sessions.

Conclusions:

  • The MSFC demonstrates high reliability for clinical use.
  • Practice effects necessitate tailored administration protocols for each component.
  • Optimized testing (1x T25FW, 3x PASAT, 4x 9HP) can enhance efficiency and accuracy.