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High Th1/Th2 ratio in patients with multiple myeloma
Hatsue Ogawara1, Hiroshi Handa, Tohru Yamazaki
1Department of Laboratory Sciences, School of Health Sciences, Faculty of Medicine, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan.
Abstract:
To determine the clinical significance of the T helper 1(Th1)/T helper 2 (Th2) ratio in multiple myeloma, the intracellular IFN-gamma and IL-4 were analyzed by flow cytometry in 56 patients with multiple myeloma. The mean Th1/Th2 ratio of cases in the initial diagnosis phase and the refractory phase were higher than that of the control group. The mean serum beta-2-microglobulin in the high Th1/Th2 subgroup was significantly higher than that in the normal Th1/Th2 subgroup (P < 0.05). In conclusion, the Th1/Th2 ratio was closely related to the disease status of multiple myeloma.