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Sildenafil citrate for erectile dysfunction in men receiving multiple antihypertensive agents: a randomized
Thomas G Pickering1, Alexander M M Shepherd, Ian Puddey
1Columbia University Medical College, New York, New York 10032, USA. tp2114@columbia.edu
American Journal of Hypertension
|December 21, 2004
Summary
Sildenafil effectively treats erectile dysfunction (ED) in men on multiple antihypertensives. This study found sildenafil citrate safe and well-tolerated for men with ED and hypertension, with no increased safety risks.
Area of Science:
- Cardiovascular Medicine
- Urology
- Pharmacology
Background:
- Erectile dysfunction (ED) is a prevalent condition affecting men undergoing treatment for hypertension.
- Antihypertensive medications can contribute to the development or exacerbation of ED.
- Evaluating ED treatments in this specific patient population is crucial for improving cardiovascular health and quality of life.
Purpose of the Study:
- To assess the safety and efficacy of sildenafil citrate in treating ED among men using multiple antihypertensive drugs.
- To compare sildenafil citrate's effectiveness against a placebo in a randomized, double-blind, controlled trial setting.
- To determine if concurrent use of multiple antihypertensives poses additional safety risks with sildenafil citrate.
Main Methods:
- A randomized, double-blind, placebo-controlled trial involving 568 men with ED and hypertension on two or more antihypertensives.
- Participants were assigned to receive either sildenafil citrate or a placebo for an initial 6-week period, followed by a 6-week open-label phase with sildenafil for all.
- Efficacy was measured using the International Index of Erectile Function (IIEF) and global efficacy assessment (GEA) questions.
Main Results:
- Sildenafil treatment significantly improved erectile function (IIEF Q3 and Q4 scores) compared to placebo after 6 weeks.
- 71% of sildenafil recipients reported improved erections (GEA1) versus 18% of placebo recipients; 69% reported improved intercourse (GEA2) versus 20%.
- Adverse events were reported by 40% of sildenafil users and 25% of placebo users, with few discontinuations due to adverse events.
Conclusions:
- Sildenafil citrate is an effective and well-tolerated treatment for erectile dysfunction in men taking multiple antihypertensive medications.
- The study indicates no increased safety risks when sildenafil citrate is used by patients on concurrent antihypertensive therapies.
- These findings support the use of sildenafil citrate as a viable treatment option for ED in hypertensive patients on complex medication regimens.