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Related Experiment Videos

Training-induced and electrically induced potentiation in the neocortex.

R A Hodgson1, Z Ji, S Standish

  • 1Department of Psychology, McMaster University, Hamilton, Ont., Canada L8S 4K1.

Neurobiology of Learning and Memory
|December 21, 2004
PubMed
Summary

Learning a motor skill enhances neural plasticity in rats, supporting the long-term potentiation (LTP) model of memory. Motor skill acquisition altered brain plasticity, suggesting LTP mechanisms underlie memory formation.

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Motor Learning

Background:

  • Long-term potentiation (LTP) is a leading laboratory model for memory.
  • Previous studies suggested motor skill learning induces LTP-like effects but lacked within-animal comparisons.

Purpose of the Study:

  • To investigate if motor skill learning induces LTP-like changes in the rat motor cortex.
  • To explore the relationship between LTP mechanisms and motor skill acquisition.

Main Methods:

  • Unilateral training of a forelimb reaching and grasping skill in Long-Evans rats.
  • Electrophysiological recordings in slice, acute, and chronic preparations to compare trained and untrained hemispheres.
  • Assessment of LTP induction and disruption of skill acquisition by LTP/LTD-inducing stimulation.

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Main Results:

  • Evoked potentials were significantly larger in the trained motor cortex hemisphere.
  • The trained hemisphere showed reduced susceptibility to subsequent LTP induction.
  • Disruption of skill acquisition occurred when LTP- or LTD-inducing stimulation was applied during training.

Conclusions:

  • Motor skill learning induces LTP-like changes in the rat motor cortex.
  • These findings provide further evidence that memory formation may rely on long-term potentiation mechanisms.