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Analysis of Human Natural Killer Cell Metabolism

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Published on: June 22, 2020

Proteomic analysis of human natural killer cells: insights on new potential NK immune functions

Jacob Hanna¹, Jonathan Fitchett, Tony Rowe

¹The Lautenberg Center for General and Tumor Immunology, Hebrew University, Hadassah Medical School, Jerusalem 91120, Israel.

Molecular Immunology

|December 21, 2004

Abstract:

Applying high-throughput proteomic analysis of mammalian cells can facilitate the identification of a large number of proteins expressed in the examined samples. Moreover, extensive research efforts are being made to perform large-scale characterization of membrane proteins. Here we use mass spectrometry-based proteomic strategy to characterize protein expression in membrane-enriched fractions derived from human NK lymphoma cell line YTS. This query yielded a list of over 1000 identified proteins, and provided us with new insights on NK cell biology. We highlight the expression of CD86 on YTS and its ability to co-stimulate TCR responses of human CD4+ T-cells, providing an unexpected link between innate and adaptive immune systems.

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