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Related Experiment Videos

The Universal Protein Resource (UniProt).

Amos Bairoch1, Rolf Apweiler, Cathy H Wu

  • 1Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland.

Nucleic Acids Research
|December 21, 2004
PubMed
Summary

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The Universal Protein Resource (UniProt) is a comprehensive database for protein sequences and functions. It offers manually curated and automatically annotated data, updated bi-weekly, with enhanced cross-references and new features like TOXIC DOSE information.

Area of Science:

  • Bioinformatics
  • Proteomics
  • Biotechnology

Background:

  • The Universal Protein Resource (UniProt) is a vital, centralized hub for protein sequence and functional data.
  • It integrates Swiss-Prot, TrEMBL, and PIR databases, offering multiple layers of protein sequence information.
  • UniProt comprises UniProt Archive (UniParc), UniProt Knowledgebase (UniProt), and UniProt Reference (UniRef) databases.

Purpose of the Study:

  • To provide the scientific community with authoritative and comprehensive protein sequence and functional information.
  • To detail the updates and new features implemented in the UniProt Knowledgebase during 2004.
  • To enhance data accessibility and integration with other biological databases.

Main Methods:

  • Manual curation and automated annotation of protein entries.

Related Experiment Videos

  • Introduction of new comment line topics (e.g., TOXIC DOSE) and keywords.
  • Standardization of post-translational modification annotation and strain documentation.
  • Integration with structural databases via residue-level mapping.
  • Provision of non-redundant (UniRef) and comprehensive (UniParc) sequence databases.

    • Main Results:

    • Tens of thousands of UniProt Knowledgebase records were manually annotated or updated.
    • New features included TOXIC DOSE information, augmented keywords, and improved documentation.
    • Enhanced cross-references and integration with structural databases were achieved.
    • UniProt databases are accessible online and via download, with bi-weekly releases.

    Conclusions:

    • UniProt serves as a critical, authoritative resource for protein data.
    • Continuous updates and new features improve the quality and utility of the database.
    • Enhanced integration and accessibility facilitate protein research.