Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

InterPro, progress and status in 2005.

Nicola J Mulder1, Rolf Apweiler, Teresa K Attwood

  • 1EMBL Outstation-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. mulder@ebi.ac.uk

Nucleic Acids Research
|December 21, 2004
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Folding the unfoldable 2: using AlphaFold and ESMFold to explore spurious proteins.

Bioinformatics advances·2026
Same author

InterProScan 6: a modern large-scale protein function annotation pipeline.

Bioinformatics advances·2026
Same author

Reducing the impact of diabetic foot ulcers (REDUCE): study protocol for an effectiveness and cost-effectiveness randomised controlled trial with embedded process evaluation.

BMJ open·2026
Same author

Viral non-coding RNA structure annotation and API-based data retrieval with Rfam and R2DT.

bioRxiv : the preprint server for biology·2026
Same author

A study protocol for a randomised controlled trial investigating the clinical effectiveness, cost effectiveness and acceptability of Behavioural Activation for Young people (BAY) in CAMHS settings.

Trials·2026
Same author

Machine Learning Models in the Prediction of Adverse Outcomes in Peripheral Arterial Disease: Meta-Analysis.

Annals of vascular surgery·2026
Same journal

Correction to 'New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress'.

Nucleic acids research·2026
Same journal

VeloRM: disentangling pre- and post-splicing RNA modification dynamics at single-cell resolution.

Nucleic acids research·2026
Same journal

Accessibility of telomeric overhangs to stabilizing small-molecule ligands.

Nucleic acids research·2026
Same journal

Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.

Nucleic acids research·2026
Same journal

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites.

Nucleic acids research·2026
Same journal

Correction to 'The Gene Ontology knowledgebase in 2026'.

Nucleic acids research·2026
See all related articles
This summary is machine-generated.

InterPro is a protein signature database integrating major resources for protein families and domains. It provides comprehensive annotation and new features like domain architecture views, covering over 78% of UniProt proteins.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Proteomics

Background:

  • Protein families, domains, and functional sites are crucial for understanding protein function.
  • Integrating diverse protein signature databases is essential for comprehensive analysis.
  • Existing resources often lack unified access and curated biological information.

Purpose of the Study:

  • To present InterPro, an integrated resource for protein families, domains, and functional sites.
  • To highlight new features and expanded content in InterPro release 8.0.
  • To improve protein annotation and analysis through a unified database.

Main Methods:

  • Manual integration of signatures from major protein databases (PROSITE, Pfam, etc.) into InterPro entries.
  • Curating entries with biological and functional information, including Gene Ontology mapping.

Related Experiment Videos

  • Developing new features such as extended protein match views, taxonomic range, and 3D structure data.

    • Main Results:

    • InterPro release 8.0 contains 11,007 entries, including domains, families, repeats, active sites, and binding sites.
    • New entry types (active site, binding site) and views (Domain Architecture) enhance descriptive capabilities.
    • InterPro covers over 78% of proteins in Swiss-Prot and TrEMBL, with ongoing integration of new member databases.

    Conclusions:

    • InterPro serves as a vital, integrated resource for protein signature analysis.
    • The database provides comprehensive, curated information and advanced features for researchers.
    • InterPro facilitates efficient protein exploration and discovery through web and FTP access.