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Updated: Aug 20, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
The SBASE domain sequence resource, release 12: prediction of protein domain-architecture using support vector
Kristian Vlahovicek1, László Kaján, Vilmos Agoston
1ICGEB-International Center for Genetic Engineering and Biotechnology, Area Science Park, 34012 Trieste, Italy.
Abstract:
SBASE (http://www.icgeb.trieste.it/sbase) is an online resource designed to facilitate the detection of domain homologies based on sequence database search. The present release of the SBASE A library of protein domain sequences contains 972,397 protein sequence segments annotated by structure, function, ligand-binding or cellular topology, clustered into 8547 domain groups. SBASE B contains 169,916 domain sequences clustered into 2526 less well-characterized groups. Domain prediction is based on an evaluation of database search results in comparison with a 'similarity network' of inter-sequence similarity scores, using support vector machines trained on similarity search results of known domains.
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