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Reactome: a knowledgebase of biological pathways.

G Joshi-Tope1, M Gillespie, I Vastrik

  • 1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. joshi@cshl.org

Nucleic Acids Research
|December 21, 2004
PubMed
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Reactome is a curated database of human biological processes, detailing reactions and pathways. It offers tools for data entry, visualization, and cross-species pathway mapping, freely available for research.

Area of Science:

  • Biotechnology
  • Bioinformatics
  • Molecular Biology

Background:

  • Reactome is a comprehensive, curated, and peer-reviewed online database.
  • It systematically catalogs human biological processes, reactions, and pathways.
  • The database provides a foundational framework for understanding complex biological systems.

Purpose of the Study:

  • To present Reactome as a resource for biological pathway data.
  • To highlight the database's structure, tools, and accessibility.
  • To emphasize its utility for both human and model organism research.

Main Methods:

  • Data curation and peer review of biological reactions and pathways.
  • Development of a data model to represent diverse human biological processes.

Related Experiment Videos

  • Creation of tools for data entry, annotation, visualization, and exploration.
  • Electronic projection of human pathways onto other organisms using orthologs.

    • Main Results:

    • Reactome provides a detailed representation of human biological processes, including metabolism, signal transduction, and the cell cycle.
    • Interactive tools enable expert annotation and visualization of pathways.
    • The resource supports research across various organisms through ortholog mapping.
    • The database and its infrastructure are publicly available under open-source terms.

    Conclusions:

    • Reactome serves as a valuable, open-source resource for exploring human biological pathways.
    • Its curated data and visualization tools facilitate biological research and discovery.
    • The cross-species applicability enhances its relevance for a broad research community.