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HAGR: the Human Ageing Genomic Resources
João Pedro de Magalhães1, Joana Costa, Olivier Toussaint
1Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Room 238, Boston, MA 02115, USA. jp@senescence.info
Nucleic Acids Research
|December 21, 2004
Summary
The Human Ageing Genomic Resources (HAGR) provides comprehensive online databases, GenAge and AnAge, detailing genes and comparative biology of ageing. These resources aid research into the genetics of human ageing and cross-species aging processes.
Area of Science:
- Genomics
- Gerontology
- Bioinformatics
Background:
- The study of human ageing requires integrated genetic and biological data.
- Existing resources for ageing research are often fragmented.
- A comprehensive, accessible platform is needed to consolidate this information.
Purpose of the Study:
- To introduce the Human Ageing Genomic Resources (HAGR) as a unified platform for ageing research.
- To describe the GenAge and AnAge databases and their associated tools.
- To facilitate the study of human ageing genetics and comparative ageing biology.
Main Methods:
- Curated compilation of ageing-related genes from literature and model organisms for GenAge.
- Integration of organismal ageing data, including lifespan and metabolism, for AnAge.
- Development of data-mining tools for genetic and cross-taxa ageing analysis.
Main Results:
- HAGR offers GenAge, a curated database of human ageing genes with detailed information.
- HAGR provides AnAge, an integrative database for comparative ageing biology across species.
- Associated data-mining tools enhance the investigation of ageing mechanisms.
Conclusions:
- HAGR serves as a valuable, freely accessible resource for the scientific community studying human ageing.
- The integrated databases and tools advance the understanding of ageing genetics and comparative gerontology.
- HAGR promotes comprehensive research into the biological processes of ageing.