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T1DBase, a community web-based resource for type 1 diabetes research.
Luc J Smink1, Erin M Helton, Barry C Healy
1Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK. Luc.Smink@cimr.cam.ac.uk
Nucleic Acids Research
|December 21, 2004
Summary
T1DBase is a public resource for type 1 diabetes (T1D) research, offering integrated genetic and expression data. It provides tools to analyze molecular genetics and pathogenesis, supporting the T1D research community.
Area of Science:
- Genomics
- Immunology
- Bioinformatics
Background:
- Type 1 diabetes (T1D) research requires comprehensive genetic and molecular data.
- Existing resources may lack integration or specific focus on T1D susceptibility and pathogenesis.
Purpose of the Study:
- To present T1DBase, a public website and database supporting the T1D research community.
- To detail the integrated datasets and bioinformatics tools available on T1DBase for T1D research.
Main Methods:
- Curated and integrated datasets including annotated genomes, genetic studies, and gene expression data.
- Development of bioinformatics tools such as genome browsers, network visualization, and data integration platforms.
- Data organization and presentation for accessibility and analysis by researchers.
Main Results:
- T1DBase provides access to annotated genomes for human, rat, and mouse.
- Includes data on T1D susceptibility regions, genetic studies, NOD mouse strains, and beta cell gene expression.
- Offers tools like GBrowse, Connect-the-Dots, and Cytoscape for data analysis and visualization.
Conclusions:
- T1DBase serves as a valuable, open-access resource for type 1 diabetes research.
- The integrated data and tools facilitate the study of T1D molecular genetics and pathogenesis.
- The platform supports collaborative research through open access and open source principles.