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Related Experiment Videos

Left axis deviation: a reassessment.

J K Perloff, N K Roberts, W R Cabeen

    Circulation
    |July 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Left axis deviation in the QRS complex is age-dependent. Ventricular weight influences early axis shifts, while conduction changes drive later leftward drift, impacting normal QRS axis interpretation.

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    Area of Science:

    • Cardiology
    • Electrocardiography
    • Human Physiology

    Background:

    • The frontal plane QRS axis reflects electrical activity of the ventricles.
    • Left axis deviation (LAD) is a common electrocardiographic finding.
    • Understanding the determinants of QRS axis is crucial for accurate interpretation.

    Purpose of the Study:

    • To elucidate the age-dependent factors influencing the frontal plane QRS axis.
    • To explain the physiological basis of left axis deviation.
    • To provide a framework for considering LAD in clinical practice.

    Main Methods:

    • Review of physiological principles governing ventricular development and conduction.
    • Analysis of the temporal relationship between ventricular weight ratios and QRS axis.

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  • Examination of the role of left anterior fascicular conduction in QRS axis drift.

    • Main Results:

    • Early QRS axis shifts are primarily determined by relative ventricular weights.
    • A period of axis stability occurs after adult ventricular weight ratios are achieved.
    • A gradual leftward QRS axis drift is observed in later life, influenced by conduction changes.

    Conclusions:

    • The normal QRS axis is not static but evolves with age.
    • Left axis deviation should be interpreted within the context of age-related physiological changes.
    • Age-dependent factors, including ventricular weight and conduction, are key to understanding LAD.