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Related Experiment Videos

Volume-induced effects on the isolated bladder: a possible local reflex.

Magdalini Lagou1, Marcus J Drake, James I Gillespie

  • 1The Urophysiology Research Group, School of Surgical and Reproductive Sciences, The Medical School, The University, Newcastle upon Tyne, UK.

BJU International
|December 22, 2004
PubMed
Summary

Bladder wall components respond to distension, influencing autonomous activity via a local reflex. This reflex involves excitatory and inhibitory elements, potentially involving interstitial cells and guanyl cyclase, but not directly motor or sensory nerves.

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Area of Science:

  • Urology
  • Physiology
  • Gastroenterology

Background:

  • The bladder wall exhibits autonomous activity, characterized by phasic pressure rises.
  • Understanding the mechanisms regulating bladder activity in response to volume changes is crucial for bladder function.
  • Local reflexes within the bladder wall are hypothesized to play a role in modulating bladder activity.

Purpose of the Study:

  • To investigate the effects of varying intravesical volume on the autonomous activity of isolated guinea pig bladders.
  • To identify the underlying mechanisms responsible for volume-induced changes in bladder activity.
  • To explore the concept of a local reflex within the bladder wall that responds to volume alterations.

Main Methods:

  • Isolated female guinea pig bladders were cannulated and maintained in vitro.

Related Experiment Videos

  • Intravesical pressure (IVP) was monitored, and drugs were added to the bathing solution.
  • Experiments included assessing the effects of volume changes, muscarinic agonists, tetrodotoxin, capsaicin, and ODQ (guanyl cyclase inhibitor).

    • Main Results:

    • Increased bladder volume augmented autonomous activity (phasic pressure rises).
    • Muscarinic agonists enhanced activity, while volume reduction caused inhibition.
    • Tetrodotoxin did not affect volume-induced changes, but capsaicin suggested sensory nerve involvement (axonal reflex).
    • ODQ treatment reduced volume-induced inhibition, indicating a potential role for guanyl cyclase and interstitial cells.

    Conclusions:

    • The bladder wall contains mechanisms that respond to distension, influencing phasic activity through a local reflex.
    • This local volume reflex appears to involve excitatory and inhibitory components, potentially mediated by interstitial cells via guanyl cyclase.
    • While not directly involving motor or sensory nerves, sensory nerves can modulate phasic activity, suggesting additional reflex pathways.