Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Integration from proteins to organs: the IUPS Physiome Project.

Peter Hunter1, Nicolas Smith, Justin Fernandez

  • 1Bioengineering Institute, University of Auckland, 70 Symonds Street, Auckland, New Zealand. p.hunter@auckland.ac.nz

Mechanisms of Ageing and Development
|December 22, 2004
PubMed
Summary

The IUPS Physiome Project offers an open-source computational physiology framework. This multi-scale modeling approach integrates organ, tissue, and cell levels for diverse physiological systems.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex differences in coordination of center of mass kinematics during table tennis footwork.

Journal of biomechanics·2026
Same author

Effect of Change of Direction (COD) Movement on Plantar Pressure and Foot Balance in Bilateral Limbs.

Journal of visualized experiments : JoVE·2026
Same author

From FAIR to CURE: guidelines for computational models of biological systems.

NPJ systems biology and applications·2026
Same author

The impact of balance exercise on brain age and brain morphometry: insights from MRI analysis.

Aging clinical and experimental research·2026
Same author

Shape variation of the human peritoneal cavity: a principal component analysis using computed tomography.

Surgical and radiologic anatomy : SRA·2026
Same author

Investigating the effectiveness of mobilisation alarms to prevent hospital falls using disinvestment: A randomised clinical trial.

International journal of nursing studies·2025

Area of Science:

  • Computational physiology
  • Systems biology
  • Bioinformatics

Background:

  • The International Union of Physiological Sciences (IUPS) Physiome Project aims to create a unified framework for computational physiology.
  • Existing physiological models often lack integration across different spatial scales and organ systems.
  • There is a need for standardized, open-source tools and databases for computational modeling in physiology.

Purpose of the Study:

  • To demonstrate the application of a multi-scale modeling framework for computational physiology.
  • To showcase the integration of organ, tissue, and cell-level data within computational models.
  • To highlight the potential of the framework for studying normal and disease-related physiological processes.

Main Methods:

  • Development of an open-source, public domain framework for computational physiology.

Related Experiment Videos

  • Application of a multi-scale modeling approach to the heart, lungs, and musculoskeletal system.
  • Incorporation of tissue and cell-level physiological data into organ-level models.

    • Main Results:

    • Successful illustration of multi-scale modeling applied to three major organ systems.
    • Demonstration of how organ-level models integrate detailed physiological information from lower levels.
    • The framework's capability to model physiological processes across different spatial scales is shown.

    Conclusions:

    • The IUPS Physiome Project provides a robust, open-source framework for computational physiology.
    • The multi-scale modeling approach effectively integrates physiological data from cellular to organ levels.
    • The framework is adaptable for studying aging and disease by modifying model parameters or adding new processes.