Related Experiment Video
Updated: Aug 20, 2026
Anesthesia and Intubation of Preadolescent Mouse Pups for Cardiothoracic Surgery
Published on: June 2, 2022
Gender may affect the hemodynamic response to induction and intubation in young adults
1Department of Anesthesiology, Yeungnam University College of Medicine, Daegu, South Korea. djee@med.yu.ac.kr
Study Objectives:
To determine whether gender affects the hemodynamic response to anesthesia induction and intubation in young adults.
Design:
Randomized clinical trial.
Setting:
University hospital.
Patients:
83 healthy patients, aged 20 to 30 years, scheduled for orthopedic, plastic, and general surgery.
Interventions:
Patients were randomly allocated to one of three groups: Anesthesia was induced with fentanyl 1.5 microg/kg and thiopental 3 mg/kg in Group 1 (n = 28, men) and Group 2 (n = 28, women), or fentanyl 1.5 microg/kg and thiopental 2 mg/kg in Group 3 (n= 27, women) and maintained with enflurane 1% in N2O-O2 throughout the observational period. Three minutes after induction, direct laryngoscopy and intubation were performed.
Measurements:
Noninvasive systolic (SBP) and diastolic (DBP) blood pressures, and heart rate (HR) were recorded before induction (baseline), immediately before intubation, immediately after intubation, and then every 1 minute for 5 minutes after intubation.
Results:
SBP, DBP, and HR did not differ between men and women at baseline. However, SBP and DBP were lower in women than in men (p < 0.05) and immediately before intubation and at overall time points after intubation. There were no significant differences noted in SBP, DBP, and HR between Groups 2 and 3. When compared with baseline values, SBP and DBP were decreased in women, whereas only DBP was decreased in men immediately before intubation (p < 0.05). The increase in SBP was more prolonged in men after intubation.
Conclusions:
Pressor response is different in women than men, suggesting the difference of the response might result from the gender differences.
