DNA sequencing of four bases using three lanes
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M Nelson1, J L Van Etten, R Grabherr
1Department of Biochemistry and Molecular Biology, University of Chicago, IL 60637.
Nucleic Acids Research
|March 25, 1992
Abstract:
A three-lane DNA sequencing strategy is described which is based on redundant binary coding principles from communications theory. Three-lane sequencing is an efficient, accurate, and flexible strategy, suitable for large-scale automated DNA sequencing. Communications theory and algebraic coding principles can also be applied to sequencing other informational macromolecules.