Related Experiment Videos
Topiramate and divalproex in combination with risperidone for acute mania: a randomized open-label study
Won-Myong Bahk1, Young-Chul Shin, Jong-Min Woo
1Department of Psychiatry, St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, South Korea.
Progress in Neuro-Psychopharmacology & Biological Psychiatry
|December 22, 2004
Summary
Topiramate combined with risperidone effectively treated acute mania, showing comparable efficacy to divalproex plus risperidone. Topiramate also avoided the weight gain associated with divalproex.
Area of Science:
- Psychiatry
- Pharmacology
- Clinical Medicine
Background:
- Mood stabilizers and atypical antipsychotics are frequently combined for bipolar mania treatment.
- Assessing alternative combinations is crucial for optimizing patient outcomes.
Purpose of the Study:
- To compare the efficacy and tolerability of topiramate plus risperidone versus divalproex plus risperidone for acute bipolar mania.
- To evaluate treatment effects on mania symptoms, global impression, and side effects like weight gain and extrapyramidal symptoms (EPS).
Main Methods:
- A naturalistic study involving 74 patients diagnosed with DSM-IV bipolar mania.
- Measurements included Young Mania Rating Scale (YMRS), Clinical Global Impression (CGI), and Simpson-Angus Rating Scale (SARS) at baseline and weeks 1, 3, and 6.
Main Results:
- Both topiramate plus risperidone group (TPMG) and divalproex plus risperidone group (DVPG) showed significant reductions in YMRS and CGI scores.
- DVPG experienced significant weight and BMI increases, unlike TPMG which showed slight decreases.
- No serious adverse events were reported in either group.
Conclusions:
- Topiramate in combination with risperidone is effective and well-tolerated for acute mania.
- Topiramate presents a promising alternative to divalproex, particularly for patients susceptible to weight gain.