Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nicotine augmentation for refractory obsessive-compulsive disorder. A case report.

Massimo Pasquini1, Alessandra Garavini, Massimo Biondi

  • 1Psychiatric Clinic III, University of Rome La Sapienza, Viale dell'Università, 30; 00185 Roma, Italy. maxpasquini@tiscalinet.it

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|December 22, 2004
PubMed
Summary

This case study shows nicotine gum may help obsessive-compulsive disorder (OCD) resistant to standard treatments. Nicotine

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Demoralization in patients with obsessive-compulsive disorder: results from an exploratory cross-sectional report.

Annals of general psychiatry·2026
Same author

The final appointment: risk factors and prevention of femicide.

Rivista di psichiatria·2026
Same author

Sweet taste hedonic response in anorexia nervosa: connections with nutritional status and psychopathology.

Eating and weight disorders : EWD·2026
Same author

Psychopathological Concomitants and Motivations Related to Misuse of Non-Steroidal Anti-Inflammatory Drugs and Paracetamol.

Human psychopharmacology·2026
Same author

Childhood Maltreatment and Suicide Risk in Migrant Psychiatric Inpatients: The Mediating Role of Depressive Symptoms.

The International journal of social psychiatry·2026
Same author

Unaware and unrestrained: binge-eating behavior in epileptic absence seizures.

Eating and weight disorders : EWD·2026

Area of Science:

  • Neuroscience
  • Psychiatry

Background:

  • Obsessive-compulsive disorder (OCD) presents significant challenges in treatment-resistant cases.
  • The precise neurobiological underpinnings of OCD, particularly the role of cholinergic systems, remain incompletely understood.

Observation:

  • A patient with severe, treatment-refractory OCD experienced notable symptom improvement.
  • This improvement was observed after the adjunctive administration of nicotine, delivered via 4 mg chewing gum.

Findings:

  • Nicotine augmentation demonstrated a positive effect on OCD symptomatology in this case.
  • The study highlights a potential, albeit unconfirmed, role for cholinergic pathways in OCD pathophysiology.

Implications:

  • Nicotine may represent a novel therapeutic avenue for individuals with refractory OCD.

Related Experiment Videos

  • Further research is warranted to explore the efficacy and mechanisms of nicotine in OCD treatment.