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Related Experiment Videos

Testosterone administration suppresses adiponectin levels in men.

Stephanie T Page1, Karen L Herbst, John K Amory

  • 1Department of Medicine, University of Washington Medical Center, Division of Endocrinology and Metabolism, 1959 NE Pacific, Box 357138, Seattle, WA 98195, USA. page@u.washington.edu

Journal of Andrology
|December 22, 2004
PubMed
Summary

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Testosterone deficiency in men increases adiponectin levels, while testosterone replacement prevents this rise. High-dose testosterone also reduces adiponectin, suggesting testosterone suppresses its production.

Area of Science:

  • Endocrinology
  • Metabolic Research

Background:

  • Testosterone (T) influences body composition, increasing lean mass and decreasing fat mass.
  • Adiponectin, produced by adipocytes, plays a role in insulin sensitivity.

Purpose of the Study:

  • To investigate the effect of experimental alterations in serum testosterone on adiponectin levels in men.
  • To determine if testosterone directly influences adiponectin production.

Main Methods:

  • Study 1: 28 healthy men (18-35 years) treated with a GnRH antagonist (acyline) to lower T levels, with and without T replacement.
  • Study 2: 25 men (55-85 years) treated with high-dose testosterone enanthate (TE).
  • Adiponectin, leptin, BMI, and T levels were measured throughout the studies.

Main Results:

Related Experiment Videos

  • Experimental testosterone deficiency increased serum adiponectin within 7 days, peaking at day 21.
  • Testosterone replacement prevented the increase in adiponectin.
  • High-dose testosterone administration decreased adiponectin levels.
  • Changes in adiponectin occurred independently of significant BMI changes.

Conclusions:

  • Serum adiponectin levels rise with experimental testosterone deficiency in men.
  • Testosterone replacement therapy prevents this increase.
  • Supraphysiological testosterone administration leads to decreased adiponectin.
  • Data support a direct suppressive role of testosterone on adipocyte adiponectin production.