Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypoxic ventilatory profile in the anesthetized rat.

M Marczak1, E E Kolesnikova, M Pokorski

  • 1Department of Respiratory Research, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland.

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
|December 22, 2004
PubMed
Summary

Hypocapnia (low CO2) does not alter the biphasic ventilatory response to hypoxia (low O2) in rats. This finding clarifies the role of CO2 in respiratory control during hypoxia, aiding future research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sexual Dimorphism in Plantar Pressure Distribution Patterns.

Physiological research·2025
Same author

Virtual Reality-Based Rehabilitation Therapy.

Physiological research·2025
Same author

[Physical rehabilitation for degenerative-dystrophic diseases of the hip joint in elderly and senile people (stage 1).]

Advances in gerontology = Uspekhi gerontologii·2024
Same author

A wise person plants a tree a day before the end of the world: coping with the emotional experience of climate change in Poland.

Current psychology (New Brunswick, N.J.)·2022
Same author

Isotonic Saline Nebulization and Lung Function in Children With Mild Respiratory Ailments.

Physiological research·2020
Same author

Clinical Significance of Gastrointestinal Carriage of Klebsiella Pneumoniae-Producing Extended-Spectrum Beta-Lactamases in Kidney Graft Recipients.

Transplantation proceedings·2018

Area of Science:

  • Physiology
  • Respiratory Control
  • Animal Models

Background:

  • Hypoxic hyperventilation often leads to hypocapnia, a decrease in carbon dioxide levels.
  • The ventilatory response to hypoxia is typically biphasic, involving initial stimulation followed by depression.
  • The influence of hypocapnia on this biphasic response remains unclear.

Purpose of the Study:

  • To investigate the effect of hypocapnia on the biphasic ventilatory response to hypoxia.
  • To determine if hypocapnia alters hypoxic ventilatory reactivity in anesthetized rats.

Main Methods:

  • Experiments conducted on anesthetized, vagotomized, spontaneously breathing rats.
  • Acute steady-state hypoxia (12% O2 in N2) was administered.
  • Ventilation, frequency, and volume components were measured via diaphragm electromyography.

Related Experiment Videos

Main Results:

  • A significant hypocapnic state developed during hypoxia.
  • The hypoxic ventilatory response remained biphasic (stimulatory/depressant).
  • The frequency component was a greater contributor to the ventilatory increase than the volume component.

Conclusions:

  • Hypocapnia does not impede hypoxic ventilatory reactivity.
  • The biphasic hypoxic ventilatory profile is preserved despite hypocapnia.
  • Findings support the use of anesthetized, poikilocapnic rat models for studying hypoxic respiratory responses.