Bioconversion of tamoxifen by microbes
1Department of Pharmacognosy, University of Mississippi, Oxford 38677.
Pharmaceutica Acta Helvetiae
|January 1, 1992
Abstract:
Screening studies of tamoxifen (TAM) have shown that only one culture, Streptomyces rimosus ATCC 2234 was able to metabolize tamoxifen to 4-hydroxy tamoxifen (OHT) which was obtained in a 10% yield and chemically identified by 2 D nmr spectroscopy. A number of microorganisms were capable of biotransforming TAM to tamoxifen-N-oxide (TNO), and desmethyltamoxifen (DMT). The chemical identity of the isolated metabolites was achieved using gas chromatography/mass spectrometry and different nmr spectroscopic techniques.
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