Related Experiment Video
Updated: May 29, 2026

Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells
Published on: June 5, 2015
Rat immunoglobulins
1Institut de Recherche sur le Cancer, INSERM U124, Place de Verdun, B.P. 3567, 59020 Lille, France.
Five immunoglobulin isotypes (or classes) have been identified in the human as well as in the rat species. The homologies between the human and the rat immunoglobulin classes have been well defined with the help of the monoclonal immunoglobulins produced by the LOU immunocytomas (plasmocytomas,myeloma tumours). The LOU rat immunocytomas model, the physicochemical and the biological properties of the rat immunoglobulins are described in this review.
Five immunoglobulin isotypes (or classes) have been identified in the human as well as in the rat species. The homologies between the human and the rat immunoglobulin classes have been well defined with the help of the monoclonal immunoglobulins produced by the LOU immunocytomas (plasmocytomas,myeloma tumours). The LOU rat immunocytomas model, the physicochemical and the biological properties of the rat immunoglobulins are described in this review.
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Antibody Structure
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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Antibodies consist of four polypeptide chains: two identical heavy...
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Antibody Structure
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
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The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.

