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High risk of recurrent venous thromboembolism in men

T Baglin1, R Luddington, K Brown

  • 1Addenbrooke's NHS Trust, Cambridge CB2 2QQ, UK. tpb20@cam.ac.uk

Journal of Thrombosis and Haemostasis : JTH
|December 23, 2004
PubMed

Insights

Men face a higher risk of recurrent venous thromboembolism (VTE) compared to women. This study highlights significant gender-based differences in VTE recurrence rates.

Area of Science:

  • Cardiovascular Medicine
  • Thrombosis Research
  • Epidemiology

Background:

  • Venous thromboembolism (VTE) is a significant health concern with varying recurrence risks.
  • Understanding factors influencing VTE recurrence is crucial for patient management.
  • Gender is a potential determinant of VTE recurrence risk.

Purpose of the Study:

  • To investigate the influence of gender on the risk of recurrence after a first episode of venous thromboembolism (VTE).

Main Methods:

  • Analysis of the Cambridge Venous Thromboembolism Study (CVTE) cohort.
  • Inclusion of unselected patients with objectively proven first VTE episodes.
  • Statistical analysis using log rank tests and hazard ratios to compare recurrence rates between genders.

Main Results:

  • Significantly higher recurrence rates observed in men compared to women (HR 2.66, P=0.0006).
  • Cumulative 2-year recurrence rate was 19.2% in men versus 7.7% in women.
  • Elevated recurrence risk in men persisted even when analyzing idiopathic VTE and considering thrombophilia status.

Conclusions:

  • The risk of recurrent VTE is demonstrably higher in men than in women.
  • Gender is an independent risk factor for VTE recurrence.
  • Further research may explore biological or lifestyle factors contributing to this gender disparity.
Abstract

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