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Related Experiment Videos

Autonomic dysfunction in migraineurs.

A Mosek1, V Novak, T L Opfer-Gehrking

  • 1Department of Neurology & Pain Control Unit, Sourasky Medical Center, Tel Aviv, Israel.

Headache
|December 23, 2004
PubMed
Summary
This summary is machine-generated.

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Migraine patients, particularly those with aura, exhibit altered autonomic nervous system function, including sympathetic hypofunction and increased sympathovagal balance during head-up tilt, potentially contributing to aura development.

Area of Science:

  • Neurology
  • Autonomic Neuroscience
  • Cardiovascular Physiology

Background:

  • Migraine pathophysiology remains largely unknown.
  • Autonomic nervous system (ANS) imbalance may underlie migraine manifestations.
  • Investigating ANS function offers insights into migraine mechanisms.

Purpose of the Study:

  • To evaluate autonomic function in migraineurs versus healthy controls.
  • To assess sympathovagal balance in individuals with and without migraine.
  • To explore potential links between ANS alterations and migraine aura.

Main Methods:

  • Autonomic function tests were performed on 17 women with migraine and 16 healthy women.
  • Tests included sympathetic function (sudomotor axon reflex, Valsalva, handgrip, cold pressor, tilt) and parasympathetic function (heart rate response to deep breathing, Valsalva).

Related Experiment Videos

  • Time-frequency analysis (Wigner distribution) was used for head-up tilt data.

    • Main Results:

    • Migraineurs with aura showed reduced blood pressure response during Valsalva maneuver (Phase IV) and handgrip test.
    • Head-up tilt revealed reduced R-R interval power at nonrespiratory frequencies in migraineurs.
    • Sympathovagal balance significantly increased in migraineurs after 10 minutes of head-up tilt.

    Conclusions:

    • Migraineurs with aura demonstrated resting supine sympathetic hypofunction with preserved parasympathetic function.
    • Head-up tilt induced an increased sympathovagal balance in migraineurs.
    • Dynamic ANS alterations may play a role in the development of migraine aura.