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Updated: Aug 20, 2026

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
Published on: June 23, 2022
Onset of amnesia is delayed with a decrease in inhibition of protein synthesis during odor-taste associative learning
Kikuo Yasui1, Ryota Matsuo, Yutaka Kirino
1Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Japan.
Abstract:
Slugs can retain odor-taste associative memory for several weeks, and this requires protein synthesis. We examined the dose-dependency of the onset time of amnesia caused by the protein synthesis inhibitor anisomycin, and showed that with reduced dose, the onset is shifted from 2 days to 3 days after conditioning; we could not shift the onset delay later than 3 days. Our results suggest that the mechanism underling memory retention is different in the period up to 3 days, versus the period later than 3 days. Our results also suggest that sustained inhibition of protein synthesis in the period from zero to 3 hr after conditioning is necessary to cause amnesia.
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