Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Hepatitis B virus surface antigen: a multifaceted protein].

Jung Hyun Park¹

¹Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. parkhy@mail.nih.gov

The Korean Journal of Hepatology

|December 23, 2004

Summary

The hepatitis B virus (HBV) surface protein has multiple functions beyond structure, aiding viral survival and pathogenesis. Understanding its diverse roles is key to combating this widespread infection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Radiologist Detection of Deficiencies in LLM-Generated Patient Communications About Radiology Reports: A Multi-Reader Study.

Journal of imaging informatics in medicine·2026

Same author

Patient-Facing Radiology Communication with LLMs: Calibration Deficit and the Metadata Paradox.

Healthcare (Basel, Switzerland)·2026

Same author

Surgically confirmed severe endometriosis is associated with lower risk of steatotic liver disease: Evidence of estrogen-linked hepatic-reproductive crosstalk.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2026

Same author

Measuring Brain Stiffness in Normal Adults According to Age and Sex Using Virtual MR Elastography: A Preliminary Study.

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine·2026

Same author

Ultraprocessed Foods and the Aging Brain: State of the Science.

Annual review of nutrition·2026

Same author

Incremental diagnostic value of multiregional single-slice CT muscle areas over L3 for sarcopenia: a deep learning-based segmentation study.

Skeletal radiology·2026

Area of Science:

Virology
Immunology
Molecular Biology

Context:

Hepatitis B virus (HBV) is a major global health threat, infecting millions despite preventive measures.
HBV's success is partly attributed to its gene products exhibiting multifunctional roles.
The HBV surface protein exemplifies this multifunctionality, with roles extending beyond its structural contribution.

Purpose:

To overview and summarize the multifaceted roles of the hepatitis B virus surface protein.
To explore how these diverse functions contribute to viral survival and pathogenesis.
To highlight the protein's significance in understanding HBV infection.

Summary:

The hepatitis B virus (HBV) surface protein acts as a structural component of the viral envelope.

Related Experiment Videos

It functions as a viral ligand, mediates nuclear transport, and acts as a transactivator potentially causing hepatocellular carcinoma.

Additional roles include apoptotic mimicry and providing B- and T-cell epitopes, contributing to immune responses.

Impact:

Understanding the versatility of the HBV surface protein is crucial for deciphering viral and immune pathogenesis.
This knowledge can inform the development of novel therapeutic strategies against HBV infection.
Elucidating these functions aids in comprehending how HBV evades the human immune system.