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Published on: December 5, 2017
Comparative studies of vasodilating effects of angiotensin-(1-7) on the different vessels
Jian-Ming Zhi1, Rong-Fang Chen, Jin Wang
1Department of Physiology, Shanghai Second Medical University, Shanghai 200025, China. zhjm169@sohu.com
Abstract:
The purpose of this study was to compare the vasodilating effects of angiotensin-(1-7) [Ang-(1-7)] on the different vessels and to clarify its mechanisms by using relaxing responses of preconstricted vascular rings. The results showed: (1) Ang-(1-7) dose-dependently induced vasorelaxation in all the vessels studied. However, there is apparent heterogeneity in the responsiveness of vessels from different origin. (2) The Ang-(1-7)-induced vasorelaxation was endothelium dependent and largely mediated by NO system. (3) The vasodilator action of Ang-(1-7) was not mediated by AT1 or AT2 receptor subtypes. It is suggested that the Ang-(1-7)-induced vasorelaxation is endothelium dependent by some other unclarified angiotensin receptor subtypes and is largely mediated by NO system.
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