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[Neuroanatomic basis for discogenic pain].
1Abteilung für Neuroanatomie und Molekulare Hirnforschung, Ruhr-Universität Bochum. pedro.faustmann@rub.de
Zeitschrift Fur Orthopadie Und Ihre Grenzgebiete
|December 23, 2004
Summary
The intervertebral disc, particularly the annulus fibrosus, is extensively innervated, with nerve ingrowth into degenerated discs contributing to chronic back pain. Post-discotomy syndrome involves denervation of paravertebral muscles.
Area of Science:
- Neuroanatomy
- Pain Medicine
- Spinal Surgery
Context:
- The intervertebral disc's role in back pain is increasingly recognized.
- Understanding the neuroanatomical basis of discogenic pain is crucial for effective treatment.
- Previous research has focused on macroscopic innervation patterns.
Purpose:
- To provide an overview of intervertebral disc innervation.
- To explore nerve connections between somatosensory and autonomic systems in the paravertebral region.
- To investigate the neuroanatomical changes in post-discotomy syndrome.
Summary:
- The annulus fibrosus and posterior longitudinal ligament are innervated by myelinated nerve fibers, with nerve ingrowth observed in degenerated discs.
- The sinuvertebral nerves, formed by somatic and autonomic roots, are the primary source of intervertebral disc innervation.
- Experimental data shows reduced neuronal markers in paravertebral muscles post-discotomy, indicating local denervation.
Impact:
- This study elucidates the neuroanatomical underpinnings of discogenic pain.
- Findings highlight the sinuvertebral nerve plexuses' role in pain signaling and spreading.
- The research provides insights into the mechanisms of post-discotomy syndrome and potential therapeutic targets.