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Updated: Aug 20, 2026

Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
Case of chronic lymphocytic leukemia with unusual chromosome aberrations
Hui-Hua Hsiao1, Yi-Hui Hung, Hui-Pin Hsiao
1Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Abstract:
Chronic lymphocytic leukemia is one of the most common leukemias in the western world and consists of many chromosome aberrations. We report the case of a 74-year-old male patient with chronic lymphocytic leukemia with complex variant translocations t(8;22)(q24;q11) and der(8)t(6;8)(p21;p21) identified by chromosome banding analysis and confirmed by fluorescence in situ hybridization analysis of interphase cells. Because of the rarity of these changes, possible molecular mechanisms associated with this karyotype are discussed.
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