Related Experiment Video
Updated: Jul 24, 2026
08:06
Study of Phagolysosome Biogenesis in Live Macrophages
Published on: March 10, 2014
[Intracellular transformation of phagosomes]
Izvestiia Akademii Nauk. Seriia Biologicheskaia
|December 24, 2004
Summary
Phagosome maturation involves dynamic protein exchange with endosomes and the biosynthetic pathway. This process equips phagosomes for essential interactions with peroxisomes, crucial for cellular defense.
Area of Science:
- Cell Biology
- Immunology
- Microbiology
Context:
- Phagosomes are key components of the innate immune system, responsible for engulfing and degrading pathogens.
- The maturation of phagosomes is a complex process involving dynamic interactions with various cellular organelles.
- Understanding phagosome transformation is vital for comprehending host-pathogen interactions and immune responses.
Purpose:
- To elucidate the molecular mechanisms governing phagosome maturation.
- To identify the key protein trafficking events that enable phagosome-peroxisome interaction.
- To provide insights into the cellular processes underlying antimicrobial defense.
Summary:
- Phagosome maturation relies on sequential interactions with early and late endosomes, facilitating protein acquisition and loss.
- Proteins are gained through interactions with the biosynthetic pathway and endosomes, and lost via recycling.
- This dynamic protein remodeling enables phagosomes to acquire the necessary properties for interacting with antimicrobial peroxisomes.
Impact:
- Reveals critical steps in phagosome maturation essential for cellular immunity.
- Highlights the importance of organelle crosstalk in immune cell function.
- Offers potential targets for therapeutic interventions against infectious diseases.
More Related Videos
Related Concept Videos
00:41Phagocytosis
Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). It is perhaps unsurprising, that many...
01:33Bacterial Transformation
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
00:41Phagocytosis
Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis ("cellular eating") is one of three major types of endocytosis. Cells use phagocytosis to take in large objects, such as other cells (or their debris), bacteria, and even viruses.
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells, including...
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells, including...
01:28Maturation of Endosomes
The early endosome containing internalized molecules matures through transformations in its location, morphology, intraluminal pH, and membrane protein composition. Together, these changes result in a more acidic late endosome that contains multiple intraluminal vesicles; therefore, the late endosome is also called a multivesicular body (MVB).
Changes in location
The maturing endosome moves along microtubules from the periphery of the cell towards the perinuclear region. This movement of the...
Changes in location
The maturing endosome moves along microtubules from the periphery of the cell towards the perinuclear region. This movement of the...
01:17Phagocytosis of Apoptotic Cells
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or immature dendritic cells. Non-professional phagocytes such as epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes.
Normal cells contain receptors that prevent them from being recognized by phagocytes.
Normal cells contain receptors that prevent them from being recognized by phagocytes.
01:26Transformation
Microbial communities are dynamic environments where cell lysis releases free DNA into the surroundings. Other cells can take up this extracellular DNA through a process known as transformation.When a cell incorporates this foreign DNA into its genome, resulting in genetic modification, the process is known as transformation. Cells capable of this process are termed competent. Competence can be natural, as observed in certain bacteria and archaea, or artificially induced in the...