Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gastric flow and mixing studied using computer simulation.

Anupam Pal1, Keshavamurthy Indireshkumar, Werner Schwizer

  • 1Department of Mechanical Engineering, 205 Reber Building, The Pennsylvania State University, University Park, PA 16802, USA.

Proceedings. Biological Sciences
|December 24, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biowaiver monograph for immediate-release solid oral dosage forms: Amlodipine besylate.

Journal of pharmaceutical sciences·2025
Same author

Unexpected effects of antibiotics on microbiota-mediated drug metabolism in a fistulated dog model.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2025
Same author

Biowaiver monograph for immediate-release solid oral dosage forms: Empagliflozin.

Journal of pharmaceutical sciences·2025
Same author

Leveraging Biopharmaceutics Bridging Risk Assessment and In Vivo Predictive Tools to Accelerate Immediate Release Drug Product Development by Minimized Need for Clinical Bridging Studies.

Molecular pharmaceutics·2025
Same author

Evaluating rat and canine microbiota models for predicting human colonic prodrug metabolism.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2025
Same author

Biowaiver monographs for immediate-release solid oral dosage forms: Voriconazole.

Journal of pharmaceutical sciences·2024
Same journal

Chronic limb loading results in remarkable load carriage economy in growing fowl.

Proceedings. Biological sciences·2026
Same journal

Motion-from-structure in face perception: expectations of natural face motion depend on face shape.

Proceedings. Biological sciences·2026
Same journal

Unification and generalization of models of zygote survival.

Proceedings. Biological sciences·2026
Same journal

Phenological type- and diameter-dependent effects of individual light availability and interannual climate variation on tree growth.

Proceedings. Biological sciences·2026
Same journal

Interaction range of common goods shapes Black Queen dynamics beyond the cheater-cooperator narrative.

Proceedings. Biological sciences·2026
Same journal

Stingray spine diversity reflects performance trade-offs linked to puncture and breakability.

Proceedings. Biological sciences·2026
See all related articles

Antral contraction waves (ACWs) are crucial for gastric mixing, creating a specific mixing zone in the stomach. Computer simulations reveal ACWs drive fluid motions, contributing to efficient mixing and potentially influencing gastric emptying.

Area of Science:

  • Gastroenterology
  • Computational Biology
  • Medical Imaging

Background:

  • The human stomach exhibits peristaltic contraction waves originating in the antrum.
  • High-resolution manometry and MRI studies suggest antral contraction wave (ACW) activity has functions beyond gastric emptying.
  • In vivo evaluation of ACW activity's role in intragastric dynamics is challenging.

Purpose of the Study:

  • To analyze the role of antral contraction waves (ACWs) in intragastric fluid motion, pressure dynamics, and mixing using computer simulation.
  • To elucidate the contribution of ACWs to gastric content homogenization.
  • To investigate the relationship between ACW activity and gastric emptying.

Main Methods:

  • Development of a two-dimensional stomach model using the lattice-Boltzmann numerical method based on MRI-derived geometry.

Related Experiment Videos

  • Simulation of gastric emptying by specifying time changes in gastric volume to match physiological rates.
  • Analysis of fluid dynamics, pressure waves, and mixing patterns within the simulated stomach.

    • Main Results:

    • Computer simulations predicted two primary fluid motions: retrograde jets through ACWs and circulatory flow between them, both enhancing mixing.
    • A distinct 'zone of mixing' confined to the antrum was identified, with mixing efficiency increasing with multiple and narrower ACWs.
    • Simulations predicted peristaltic pressure waves in the distal antrum, but with lower amplitude than manometric data, suggesting manometry reflects direct catheter-wall contact.

    Conclusions:

    • Antral contraction waves (ACWs) are fundamental to gastric mixing processes.
    • ACWs establish a localized mixing zone within the antrum.
    • ACWs may indirectly influence gastric emptying by altering local intragastric pressure.