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Published on: March 25, 2022
Balloon dilatation of biliary-enteric strictures in children
Jonathan M Lorenz1, Gregory Denison, Brian Funaki
1Department of Radiology, The University of Chicago Hospitals, 5841 S. Maryland Ave., MC 2026, Chicago, IL 60637, USA. jonathanlorenz@hotmail.com
Insights
Balloon dilatation effectively treats biliary-enteric strictures after pediatric liver transplants, achieving long-term patency in over half of cases without complications. This minimally invasive approach offers a safe alternative to surgery for these liver transplant recipients.
Area of Science:
- Pediatric Gastroenterology
- Transplant Surgery
- Interventional Radiology
Background:
- Biliary-enteric strictures are a common complication after pediatric liver transplantation.
- These strictures can lead to graft dysfunction and failure.
- Current treatment options include surgical revision, which can be invasive.
Purpose of the Study:
- To evaluate the efficacy and safety of balloon dilatation for treating biliary-enteric strictures in pediatric liver transplant recipients.
- To determine the long-term patency rates after balloon dilatation.
- To assess the complication rate associated with the procedure.
Main Methods:
- A retrospective study of 19 children (20 strictures) who underwent balloon dilatation for biliary-enteric strictures.
- Dilatation was performed at a mean of 2.6 years post-anastomosis.
- Follow-up ranged from 1.4 to 5.4 years.
Main Results:
- 100% technical success with no procedure-related complications.
- 58% of patients achieved biliary-enteric patency at one year post-dilatation.
- 40% of strictures persisted, requiring further intervention such as surgery or stenting.
Conclusions:
- Balloon dilatation is a safe and effective treatment for biliary-enteric strictures in pediatric liver transplant patients.
- It offers a high success rate and avoids complications associated with surgery.
- This technique provides a valuable minimally invasive option for managing post-transplant biliary complications.
Objective:
The objective of our study was to evaluate the efficacy and safety of balloon dilatation in the treatment of anastomotic strictures in children with liver transplants.
Materials And Methods:
For a period of 7 years, we treated 20 consecutive biliary-enteric strictures in 19 children (age range, 13 months to 17.9 years, mean, 7.3 years) with balloon dilatation. Dilatation was performed between 30 days and 8.4 years (mean, 2.6 years) following surgical creation of the biliary-enteric anastomosis. Thirteen patients had left lateral segment liver transplant grafts, one patient had a split-liver, left-lobe graft, and five patients had whole liver grafts.
Results:
Technical success was 100% and there were no procedure-related complications. One patient with a patent anastomosis underwent repeat transplantation 183 days after the procedure for chronic rejection. In 58% (11/19) of the remaining procedures, balloon dilatation resulted in biliary-enteric patency at one year, and continued patency ranges from 1.4 to 5.4 years (mean, 3.6 years). In 40% (8/20) of the procedures, the biliary-enteric stricture persisted after balloon dilatation, and these patients eventually underwent surgical revision, retransplantation, or endobiliary metallic stent placement.
Conclusion:
Balloon dilatation is a safe and effective treatment for biliary-enteric strictures following pediatric liver transplantation.
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