Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vasopressin in the ICU.

Cheryl L Holmes1, Keith R Walley

  • 1Department of Medicine, University of British Columbia, Vancouver, Department of Medicine, Kelowna General Hospital, Kelowna, BC, Canada. clholmes@shaw.ca

Current Opinion in Critical Care
|December 24, 2004
PubMed
Summary

Vasopressin infusion is increasingly recognized as safe and effective for septic shock, with evidence supporting its use as a continuous low-dose infusion. However, its role in vasodilatory shock remains under investigation, prompting cautious clinical application.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety of intravascular administration of umbilical-cord-derived mesenchymal stromal cells: an updated systematic review and meta-analysis.

Stem cells translational medicine·2026
Same author

Correction: Plasma apolipoprotein A-I is a causal protective factor in sepsis.

Scientific reports·2026
Same author

Causal effects of serum testosterone on septic shock mortality: a Mendelian randomization study.

Critical care (London, England)·2026
Same author

Plasma apolipoprotein A-I is a causal protective factor in sepsis.

Scientific reports·2025
Same author

Obesity- and Lipid-Related Traits May Causally Contribute to Sepsis-Associated Acute Kidney Injury.

Critical care medicine·2025
Same author

Decreased Clearance of Low-Density Lipoprotein Cholesterol is Causally Associated With Increased Mortality of Septic Shock.

Critical care medicine·2025

Area of Science:

  • Critical Care Medicine
  • Pharmacology
  • Emergency Medicine

Background:

  • Vasopressin is a key endogenous stress hormone released during shock states.
  • Understanding its role in intensive care unit (ICU) settings is crucial for patient management.

Purpose of the Study:

  • To review recent studies on the use of vasopressin in the ICU.
  • To synthesize current evidence regarding vasopressin's efficacy and safety in various shock conditions.

Main Methods:

  • Review of studies published within the past year.
  • Analysis of clinical trials and animal models related to vasopressin in shock.

Main Results:

  • Endogenous vasopressin levels are often low in adults with severe sepsis.

Related Experiment Videos

  • Vasopressin, particularly in combination with norepinephrine, shows promise in improving hemodynamics and survival in septic shock models and human vasodilatory shock.
  • Potential adverse effects include gastrointestinal hypoperfusion and skin lesions; high-dose bolus use in cardiopulmonary arrest yielded controversial neurologic outcomes.

    • Conclusions:

    • Growing evidence supports the safety and efficacy of continuous low-dose vasopressin infusion in septic shock.
    • Clinical equipoise exists regarding vasopressin's use in vasodilatory shock.
    • Current guidelines recommend cautious use of vasopressin in septic shock management pending further research.