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Hospitalization and infant outcomes among women exposed and unexposed to tocolysis
Brian Coleman1, Therese Grant, Beth Mueller
1Division of Emergency Medicine, Children's Hospital and Regional Medical Center, University of Washington, Seattle, WA 98105, USA.
Objective:
To examine whether infants exposed to tocolytics are at increased risk for selected adverse clinical and hospitalization outcomes.
Study Design:
We conducted a population-based cohort study of women with preterm labor, in Washington State from 1989 to 2001 (N=79,679), using linked hospitalization records. Relative risks for infant outcomes were estimated using multivariate logistic regression.
Results:
Adjusted risk estimates for infants exposed to tocolysis were greater for respiratory distress (RR=1.5, 95% CI 1.4 to 1.6), intubation (RR=1.4, 95% CI 1.2 to 1.5), and bacterial infection (RR=1.6, 95% CI 1.4 to 1.8). Exposed infants were also more likely to have birth hospitalizations >2 days (RR=1.4, 95% CI 1.3 to 1.4), require transfer (RR=1.5, 95% CI 1.3 to 1.8), have increased hospital costs (RR=2.3, 95% CI 2.2 to 2.4), and require readmisssion within the first year of life (RR=1.2, 95% CI 1.1 to 1.3).
Conclusion:
Infants exposed to tocolytics appeared to have relatively poorer hospitalization and clinical outcomes; significant benefits were not observed.
