Related Experiment Video
Updated: Feb 7, 2026
06:45
Quantifying the Antifungal Activity of Peptides Against Candida albicans
Published on: January 13, 2023
2.9K
Advances in antifungal chemotherapy
1Merck Research Laboratories, Rahway, New Jersey 07065-0900, USA.
Drug News & Perspectives
|December 24, 2004
Summary
The 38th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) showcased research on fungal disease pathogenesis and new antifungal drugs. Studies evaluated in vitro and in vivo activity of azoles, echinocandins, and polyenes, alongside clinical data for established agents.
Area of Science:
- Mycology
- Infectious Diseases
- Pharmacology
Background:
- Fungal infections pose significant health challenges, necessitating the development of novel antifungal therapies.
- Established antifungal agents have limitations, driving research into new drug classes.
- Understanding fungal pathogenesis is crucial for effective treatment strategies.
Purpose of the Study:
- To present and discuss the latest research on fungal disease pathogenesis.
- To evaluate the in vitro and in vivo efficacy of emerging antifungal agents.
- To review the clinical applications of current and novel antifungal drugs.
Main Methods:
- In vitro susceptibility testing of new azole, echinocandin-like, and polyene antifungal agents.
- Experimental in vivo studies assessing the activity of new antifungal drugs in animal models.
- Clinical data analysis of established antifungals like fluconazole and itraconazole.
Main Results:
- Voriconazole, Syn-2869, SCH-56592, carbendazim (azoles), FK-463, LY-303366, MK-0991 (echinocandins), and patricins (polyenes) demonstrated varying in vitro activity.
- Promising in vivo efficacy was observed for several new antifungal candidates in preclinical models.
- Clinical data highlighted the effectiveness of fluconazole, itraconazole, and liposomal amphotericin B.
Conclusions:
- The 38th ICAAC highlighted significant advancements in antifungal drug development and understanding of fungal infections.
- New azole and echinocandin-like agents show potential for treating challenging fungal diseases.
- Continued research and clinical evaluation are essential for optimizing antifungal therapy.
Related Concept Videos
01:21Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
790
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
790
02:22Overview of Advanced Functional Groups
30.1K
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
30.1K
00:56Extraction: Advanced Methods
1.2K
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.2K
01:29Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
890
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
Phenothiazines, such as prochlorperazine...
890
01:27Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
681
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
681
01:08Sample Preparation for Analysis: Advanced Techniques
1.5K
Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
1.5K