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Updated: Aug 20, 2026

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
Published on: December 15, 2023
High prevalence of hepatitis B virus infection among tuberculosis patients with and without HIV in Rio de Janeiro,
C A Blal1, S R L Passos, C Horn
1Departamento de Micro-Imuno-Parasitologia, Serviço de Imunologia, Instituto de Pesquisa Clínica Evandro Chagas, Fiocruz, Avenida Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil.
Abstract:
To determine the prevalence and exposure factors associated with hepatitis B infection in tuberculosis patients with and without HIV type 1 coinfection, the presence of hepatitis B virus serological markers was investigated in a retrospective study. The seroprevalence of hepatitis B virus in patients with tuberculosis only was 14.6%, and in tuberculosis patients coinfected with HIV it increased to 35.8%. In patients with HIV and tuberculosis coinfection, homosexuality constituted the principal exposure factor, while in tuberculosis patients without HIV, a gradual increase in hepatitis B virus seroprevalence was noted along with increasing age. The results demonstrate that hepatitis B infection is highly prevalent in tuberculosis patients in Brazil and suggest that a vaccination program for the general population should be considered in order to prevent further hepatitis B infections.
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