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Progress in boronic acid-based fluorescent glucose sensors.

Hao Fang1, Gurpreet Kaur, Binghe Wang

  • 1Department of Chemistry, MSC 8L0378, Georgia State University, 33 Gilmer St. SE, Atlanta, Georgia 30303-3083, USA.

Journal of Fluorescence
|December 25, 2004
PubMed
Summary

Continuous, non-invasive blood glucose monitoring is crucial for diabetes management. This review highlights advancements in implanted glucose fluorescent sensors, particularly those utilizing boronic acid chemistry for accurate detection.

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Materials Science

Background:

  • Effective diabetes management requires frequent blood glucose monitoring.
  • Current in vitro methods are invasive and problematic.
  • There is a significant need for non-invasive, continuous glucose monitoring solutions.

Purpose of the Study:

  • To review recent progress in non-invasive glucose monitoring technologies.
  • To focus on the development of implanted glucose fluorescent sensors.
  • To highlight the role of boronic acid functional groups in sensor design.

Main Methods:

  • Literature review of scientific publications over the last ten years.
  • Analysis of sensor designs incorporating boronic acid chemistry.

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  • Evaluation of fluorescent sensing mechanisms for glucose detection.

    • Main Results:

    • Implanted glucose fluorescent sensors show significant promise for continuous monitoring.
    • Boronic acid functional groups are critical for effective glucose binding and sensing.
    • Recent advancements have improved sensor sensitivity and stability.

    Conclusions:

    • Non-invasive glucose monitoring via implanted sensors is a rapidly advancing field.
    • Boronic acid-based fluorescent sensors offer a viable path towards improved diabetes care.
    • Further research is needed to optimize sensor performance and clinical translation.