[Relationship between human cytomegalovirus infection and soluble interleukin-2 receptor level]

In order to study the relationship between human cytomegalovirus infection and soluble interleukin-2 receptor (sIL-2R) level, 104 serum samples were selected from women of childbearing age in the city of Wuhan and examined with ELISA for anti-HCMV antibody IgG and IgM. Then we detected the sIL-2R level with double antibody ELISA in these sera with different conditions of HCMV infection. The results of different groups were compared with those women without cytomegalovirus infection and also compared with each other. The positive rate for anti-HCMV antibody IgG in the women of Wuhan was 89.4% (93/104) and for anti-HCMV antibody IgM only was 9.6% (10/104). The sIL-2R level of these women with HCMV infection was significantly higher than that in the control group (178.1 +/- 57.3 U/ml), P > 0.05. The highest level of sIL-2R were in those women whose anti-HCMV antibody IgM were positive (910 +/- 465.6 U/ml) and secondly was in those with anti-HCMV antibody IgG, IgM positive (905 +/- 347.8 U/ml). They were both higher than that in those women only with anti-HCMV antibody IgG positive (446.8 +/- 158.9 U/ml), P > 0.05. The results showed that HCMV infection can raise the sIL-2R level in serum of childbearing age women, especially in those with active HCMV infection. sIL-2R may be one of the pathogenic factors of HCMV.