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Large loop excision and cold coagulation for management of cervical intraepithelial neoplasia
M Allam1, A Paterson, A Thomson
1Department of Obstetrics and Gynaecology, Royal Alexandra Hospital, Corsebar Road, Paisley, PA2 9PN, UK.
Objectives:
To evaluate the efficacy of large loop excision of the transformation zone (LLETZ) combined with a single application of the cone probe of a Semm Cold Coagulator as a new treatment for women with cervical intraepithelial neoplasia (CIN).
Methods:
Retrospective case-record review of 666 women treated with large loop excision and cold coagulation (LLECC) from 1992 to 2000.
Results:
Of the women who had high-grade CIN at their initial consultation, 4.2% had abnormal cytologic results 6 months after treatment and 0.6% had abnormal cytologic results at 12 months. Of the women who had low-grade CIN at initial presentation, 3.8% had abnormal cytologic results 6 months after treatment and none (0%) at 12 months. Furthermore, there were no reported cases of cervical cancer in this cohort of women during the follow-up period. Short-term bleeding complications (within 24 h of the procedure) occurred in 1% of the women assessed.
Conclusions:
Large loop excision combined with cold coagulation is a new and effective treatment for CIN. Randomized controlled trials are required to confirm these findings and determine the long-term safety of the technique.
