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Temporal order judgment in mice.

Makoto Wada1, Shunjiro Moizumi, Shigeru Kitazawa

  • 1Department of Physiology, School of Medicine, Juntendo University, Hongo 2-1-1, Tokyo 113-8421, Japan.

Behavioural Brain Research
|December 25, 2004
PubMed
Summary
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Mice can learn to distinguish the timing of touch sensations on their whiskers. This tactile temporal order judgment suggests a potential right-brain dominance for processing sequential stimuli.

Area of Science:

  • Neuroscience
  • Animal Behavior

Background:

  • Assessing temporal order judgment in rodents is crucial for understanding sensory processing.
  • Previous research has primarily focused on auditory and visual stimuli, with less known about tactile temporal perception.

Purpose of the Study:

  • To develop and validate a novel temporal order judgment task for mice using tactile whisker stimulation.
  • To investigate the capacity of mice to discriminate the order of bilateral tactile stimuli and explore potential hemispheric lateralization.

Main Methods:

  • A custom-built apparatus delivered controlled air puffs to mouse whiskers in specific temporal sequences (R-L, L-R, L-L, R-R).
  • Mice were trained to respond to the first or second stimulus based on a go signal, with performance assessed over 50 days.
  • Whiskers were removed to confirm the role of tactile input, and successful mice were tested with varying inter-stimulus intervals.

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Main Results:

  • All mice successfully learned to discriminate unilateral stimuli (L-L, R-R).
  • Nine out of fifteen mice achieved criterion for bilateral stimuli (L-R, R-L), with median training times of 15 and 34 days, respectively.
  • Tactile temporal resolution was determined to be 160 ms, with a bias towards judging simultaneous stimuli as left-first, suggesting right-hemisphere involvement.

Conclusions:

  • Mice possess the ability to learn and perform a temporal order judgment task based on tactile whisker input.
  • The observed bias in temporal order judgment indicates a potential lateralization of this sensory processing to the right cerebral hemisphere.