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Related Experiment Videos

Human peripheral blood eosinophils induce angiogenesis.

Ilaria Puxeddu1, Akram Alian, Adrian Martin Piliponsky

  • 1Department of Pharmacology, Faculty of Medicine, School of Pharmacy, The Hebrew University of Jerusalem, POB 12065, Jerusalem 91120, Israel.

The International Journal of Biochemistry & Cell Biology
|December 25, 2004
PubMed
Summary

Eosinophils directly contribute to angiogenesis, the formation of new blood vessels. This process, partially mediated by vascular endothelial growth factor, is crucial in diseases like asthma.

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Area of Science:

  • Immunology
  • Cell Biology
  • Vascular Biology

Background:

  • Eosinophils are key players in allergic reactions, asthma, and other inflammatory conditions.
  • Angiogenesis, or new blood vessel formation, is increasingly recognized as important in these diseases.
  • Eosinophils produce mediators that can influence blood vessel growth.

Purpose of the Study:

  • To investigate the direct role of eosinophils in promoting angiogenesis.
  • To determine if eosinophil-derived vascular endothelial growth factor (VEGF) contributes to their pro-angiogenic activity.

Main Methods:

  • Assessing the impact of human eosinophil sonicates on endothelial cell proliferation (in vitro).
  • Evaluating rat aorta sprouting (ex vivo) and chick embryo chorioallantoic membrane assays (in vivo).

Related Experiment Videos

  • Investigating the effect of anti-VEGF antibodies on eosinophil-induced angiogenesis and measuring VEGF mRNA and receptor expression.

    • Main Results:

    • Eosinophils significantly enhanced endothelial cell proliferation and induced robust angiogenesis in multiple models.
    • Neutralizing VEGF with antibodies partially inhibited the angiogenic response.
    • Eosinophils stimulated vascular endothelial growth factor mRNA production in endothelial cells.

    Conclusions:

    • Eosinophils possess the ability to induce angiogenesis.
    • This pro-angiogenic effect is, in part, mediated by pre-formed vascular endothelial growth factor released by eosinophils.
    • Eosinophils likely play a significant role in angiogenesis-associated diseases, including asthma.