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Left ventricular concentric geometry is associated with impaired relaxation in hypertension: the HyperGEN study

Giovanni de Simone1, Dalane W Kitzman, Marcello Chinali

  • 1Weill Medical College of Cornell University, New York, NY, USA. simogi@unina.it

European Heart Journal
|December 25, 2004
PubMed

Insights

Abnormal left ventricular (LV) relaxation is linked to concentric LV geometry in hypertensive individuals. This finding highlights the importance of assessing LV geometry for understanding relaxation abnormalities.

Area of Science:

  • Cardiology
  • Cardiovascular Physiology
  • Echocardiography

Background:

  • Hypertension is a major risk factor for cardiovascular disease.
  • Left ventricular (LV) geometry and relaxation are key indicators of cardiac health.
  • Understanding the relationship between LV geometry and relaxation is crucial for early detection and management of cardiovascular complications.

Purpose of the Study:

  • To investigate the association between abnormal left ventricular (LV) relaxation and concentric LV geometry.
  • To determine if LV hypertrophy influences this relationship.

Main Methods:

  • Doppler echocardiography was used to assess LV filling properties in 1384 hypertensive participants.
  • Participants were categorized into four LV geometry groups: normal, concentric remodeling, eccentric, and concentric LV hypertrophy.
  • Abnormal LV relaxation was identified using European Society of Cardiology criteria.

Main Results:

  • Delayed LV relaxation was significantly associated with concentric LV geometry (P<0.0001).
  • While LV hypertrophy prolonged deceleration time, the relationship with concentric geometry differed based on hypertrophy presence.
  • Concentric LV geometry increased the odds of abnormal LV relaxation by 2.3-fold.

Conclusions:

  • Delayed LV relaxation is independently associated with concentric LV geometry in hypertensive individuals without cardiovascular disease.
  • These findings suggest that concentric LV geometry is a significant predictor of abnormal LV relaxation.
Abstract

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