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Related Experiment Video

Updated: Jul 21, 2026

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
09:55

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

Mouse brain organization revealed through direct genome-scale TF expression analysis.

Paul A Gray1, Hui Fu, Ping Luo

  • 1Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|December 25, 2004
PubMed
Summary

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Researchers mapped over 1000 mouse transcription factors (TFs) and TF-coregulator genes in developing brains. A subset of 349 TFs revealed restricted expression patterns, aiding in understanding brain anatomical organization.

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Biology

Background:

  • Transcription factors (TFs) are crucial for cell differentiation in the developing brain.
  • Understanding TF expression patterns is key to deciphering brain development and organization.

Purpose of the Study:

  • To identify and map the expression of transcription factors in the developing mouse brain.
  • To correlate TF expression patterns with the anatomical organization of the brain.

Main Methods:

  • Genome-wide identification of putative transcription factors in the mouse.
  • In situ hybridization to visualize gene expression in developing mouse brains.
  • Creation of a searchable brain atlas database for TF expression patterns.

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Related Experiment Videos

Last Updated: Jul 21, 2026

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
09:55

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
08:06

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Published on: February 15, 2021

Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy
08:49

Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy

Published on: August 1, 2022

Main Results:

  • Identified 1445 putative transcription factors in the mouse genome.
  • Mapped expression patterns for over 1000 TFs and TF-coregulator genes.
  • Found 349 TFs with restricted expression patterns correlating to brain anatomy.

Conclusions:

  • A significant number of transcription factors exhibit spatially restricted expression in the developing brain.
  • This comprehensive atlas provides a valuable resource for studying brain development and TF function.
  • The identified TF expression patterns offer insights into the anatomical organization of the murine brain.