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Related Experiment Videos

MRI diffusion coefficients in spinal cord correlate with axon morphometry.

Eric D Schwartz1, Emily T Cooper, Yingli Fan

  • 1Department of Radiology, University of Pennsylvania School of Medicine, 1 Silverstein, 3400 Spruce St, Philadelphia, PA 19104, USA. eric.schwartz@uphs.upenn.edu

Neuroreport
|December 25, 2004
PubMed
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Diffusion MRI (DWI) shows promise for detecting spinal cord injury and treatment effects. This study correlates directional apparent diffusion coefficients (ADC) with axon morphometry, revealing DWI

Area of Science:

  • Neuroimaging
  • Histology
  • Spinal Cord Injury Research

Background:

  • Diffusion MRI (DWI) can detect spinal cord injury and neuroprotection missed by conventional MRI.
  • Histologic correlates of directional apparent diffusion coefficients (ADC) from DWI are not well-established.

Purpose of the Study:

  • To determine the histologic basis of directional ADC values in the spinal cord.
  • To correlate ADC measurements with axon morphometry in the normal rat cervical spinal cord.

Main Methods:

  • Diffusion MRI (DWI) was used to obtain apparent diffusion coefficients (ADC).
  • ADC values were measured in directions transverse and longitudinal to axons.
  • ADC values were correlated with axon counts and morphometry in the rat cervical spinal cord.

Related Experiment Videos

Main Results:

  • Both transverse and longitudinal ADC values correlated significantly with axon counts.
  • Each directional ADC measurement reflected distinct histologic parameters related to white matter integrity.

Conclusions:

  • Directional ADC values obtained via DWI are linked to specific histologic features of white matter.
  • DWI has the potential to provide detailed histologic information about white matter integrity following injury.