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B-type natriuretic peptide and long-term survival in patients with stable coronary artery disease

Torbjørn Omland1, A Mark Richards, Ragnhild Wergeland

  • 1Cardiology Division, Department of Medicine, Akershus University Hospital, University of Oslo, Oslo, Norway. torbjorn.omland@klinmed.uio.no <torbjorn.omland@klinmed.uio.no>

The American Journal of Cardiology
|December 28, 2004
PubMed

Insights

Plasma B-type natriuretic peptide (BNP) levels predict long-term survival in patients with stable coronary artery disease. Higher BNP indicates increased mortality risk, independent of other factors.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Research

Background:

  • Circulating B-type natriuretic peptide (BNP) is a recognized predictor of survival in acute coronary syndromes and heart failure.
  • The prognostic value of BNP in clinically stable coronary artery disease (CAD) with angiographic documentation remains uncertain.

Purpose of the Study:

  • To investigate whether plasma BNP levels predict long-term survival in patients with stable, angiographically confirmed coronary artery disease.

Main Methods:

  • A cohort of 186 patients with stable angina and significant CAD were followed for 7.4 years.
  • Exclusion criteria included recent myocardial infarction, active ischemia, rest angina, or heart failure.
  • Cox proportional-hazards regression and stepwise forward multivariate analysis were used to assess predictors of mortality.

Main Results:

  • Twenty-three deaths occurred during follow-up.
  • Age, Q waves on ECG, left ventricular ejection fraction, and plasma BNP were significantly associated with long-term survival.
  • Plasma BNP independently predicted survival, even when accounting for conventional risk markers.

Conclusions:

  • Plasma BNP levels are an independent predictor of long-term survival in patients with stable, angiographically documented coronary artery disease.
  • BNP offers valuable prognostic information beyond traditional risk factors in this patient population.

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