Related Experiment Video
Updated: Aug 20, 2026
Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis
Published on: March 31, 2015
[Research on the expression of c-myc mRNA in ameloblastoma]
Zi-juan Li1, Ming Zhong, Jie Wang
1Department of Pathology, College of Stomatology, China Medical University, Shengyang 110002, China.
Purpose:
To study the expression of c-myc mRNA in ameloblastoma (AB) and odontogenic keratocyst (OKC) and to investigate the genesis, development and biological characteristics of AB and OKC.
Methods:
We detected c-myc mRNA in 54 cases of AB (31 primary ABs, 19 recurrent Abs and 4 malignant ABs), 16 cases of OKC and 7 cases of normal oral mucosa (NOM) by in situ hybridization. Chi2 test was used to analyze the results.
Results:
The positive rate of AB, OKC and NOM was 81.5% (44/54), 75.0% (12/16) and 14.3% (1/7), respectively. There was statistical difference among three groups (chi2=15.488, P<0.05). Comparing the expression of primary AB (71.0%) with recurrent (94.7%), malignant AB (100.0%), there was a significant statistical difference (chi2=16.912, P<0.05).
Conclusions:
The expression of c-myc is important to the genesis and development of AB; following the change of primary, recurrent and malignant AB, the expression of c-myc mRNA increased significantly.It is suggested that c-myc mRNA may be an effective marker to evaluate the prognosis of AB.
