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Updated: Jun 20, 2026
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
Published on: February 18, 2015
[Relationship between the genotype of Candida albicans and oral lichen planus]
Lan Wu1, Zeng-tong Zhou, Guo-yao Tang
1Department of Oral Medicine, Ninth People's Hospital, School of Stomatology, Shanghai Second Medical University, Shanghai 200011, China.
Purpose:
The present study was attempted to probe into the relation between the genotype of Candida albicans and oral lichen planus, analyze the relativity of the genotype between commensal strains and pathogenic strains, to lay a good foundation for the prevention and treatment for candidiasis.
Methods:
The present study adopted random amplified polymorphic DNA (RAPD) to analyze 46 Candida species which were isolated from the oral cavity of 9 health adults (N group) and the patients suffering from oral mucosal disease (including 16 lichen planus, LP group and 21 oral candidiasis, OC group).
Results:
40 strains were identified as Candida albicans. Different candida species emerged with different genetic types. The genotype of the OC group and N group were similar, genetic homology exits between OC group and N group. There was no distinct similarity in RAPD fingerprinting map of the LP group, which also had significant difference to the genotype of the N group (P<0.001). There was significant difference between OC group and LP group (P<0.001).
Conclusion:
(1) The RAPD genotype not only can discriminate candida species, but also can distinguish further different types in the same species. (2) Oral candidiasis may originate from commensal strains. Candida albicans isolated from oral candidiasis were endogenous. (3) According to the results of genotypes, there might be no genetic homology between commensal strains and pathogenic strains in LP group. (4) The genotypes of pathogenic strains were not identical in different kinds of oral mucosa diseases.
