Related Experiment Video

Updated: Aug 20, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
05:53

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

[The carcinogenesis of human cytomegalovirus to mouse cervix]

Z Wang1, Y Sun, D Lu

  • 1Department of Oncogenic Virus Research Institute, Hubei Medical University, Wuhan 430071.

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology
|March 1, 1997
PubMed

Insights

Human cytomegalovirus (HCMV) infection in mice led to cervical carcinomas. This study investigated the oncogenic potential of HCMV, finding a link between viral infection and cancer development.

Area of Science:

  • Virology
  • Oncology
  • Immunology

Context:

  • Human cytomegalovirus (HCMV) is a common herpesvirus with suspected links to various cancers.
  • Cervical cancer remains a significant global health concern, with viral infections implicated in its pathogenesis.

Purpose:

  • To investigate the potential of UV-inactivated human cytomegalovirus (HCMV) to induce cervical carcinomas in a mouse model.
  • To evaluate the correlation between HCMV infection, carcinogenesis, and immune responses.

Summary:

  • Mice infected with UV-inactivated HCMV developed cervical carcinomas, with a 15% incidence rate.
  • Co-administration of croton oil with HCMV increased carcinogenesis to 18.8%, compared to 0% in controls.
  • HCMV immediate early (IE) antigen and IE antibody titers were positive in infected mice with tumors, while absent in controls.
  • Decreased ANAE positive rates in lymphocytes were observed in HCMV-infected mice.

Impact:

  • This research provides evidence for the oncogenic potential of HCMV in cervical carcinogenesis.
  • Findings suggest HCMV may play a role in the development of cervical cancer, warranting further investigation.
  • The study highlights the importance of understanding viral contributions to cancer etiology.

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