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Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
Published on: July 11, 2025
[Imported malaria: prevention should strengthened]
C Godet1, G Le Moal, M H Rodier
1Service de médecine interne et maladies infectieuses, CHU La Milétrie, rue la Milétrie, 86021 Poitiers, France.
Introduction:
The risk of acquiring malaria infection can largely be prevented by the regular use of chemoprophylactic drugs combined with protective measures against mosquito bites. In a retrospective study we had for aim to evaluate the compliance to malaria chemoprophylaxis in patients presenting with malaria infection.
Methods:
We analyzed the compliance to the recommended malaria chemoprophylaxis of French travelers hospitalized in a department of infectious diseases because of malaria infection, between January 1999 and December 2003.
Results:
Eighty-five patients, with a mean age of 34.1 years (16-65) were treated for malaria infection. Seventy-seven were due to Plasmodium falciparum. The outcome was favorable for all patients, despite four severe accesses. Forty-six patients (54%) did not take any chemoprophylaxis (CP), 19 (22%) had an inadequate CP for the risk, 13 (15%) badly complied with intermittent intake of CP and seven (8%) complied well with the recommended malaria CP. Among the 85 patients, 27 (32%) had come to the travelers' consultation and been given recommendations and a recommended malaria CP prescription before traveling.
Conclusion:
These results confirm that the majority of imported malaria cases is a consequence of bad compliance to CP. Understanding user profiles and factors predicting non-compliance may help us to improve pretravel counseling, thereby reducing the risk for travelers to acquire malaria infection.
Insights
Most imported malaria cases result from poor adherence to malaria chemoprophylaxis (CP). Improving pre-travel counseling on CP is crucial for reducing malaria risk in travelers.
Area of Science:
- Infectious Diseases
- Travel Medicine
- Public Health
Context:
- Malaria infection risk is preventable with chemoprophylaxis and mosquito bite protection.
- A retrospective study evaluated malaria chemoprophylaxis compliance in infected travelers.
Purpose:
- To assess compliance with recommended malaria chemoprophylaxis among French travelers hospitalized with malaria.
- To identify factors contributing to malaria infection in travelers.
Summary:
- Eighty-five malaria patients were analyzed; 54% reported no chemoprophylaxis, 22% had inadequate prophylaxis, and 15% had poor intermittent adherence.
- Only 8% demonstrated good compliance with recommended malaria chemoprophylaxis.
- 32% of patients had consulted prior to travel and received prophylaxis recommendations.
Impact:
- Findings highlight poor chemoprophylaxis compliance as a primary cause of imported malaria.
- Understanding non-compliance factors can enhance pre-travel advice and reduce malaria incidence in travelers.
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